Jo Cameron
Jo Cameron (born 1948; age 77–78 years), also known as Patient PFS, is a Scottish woman who feels no pain and experiences little to no anxiety or other aspects of negative affect.
She has two mutations, one in the gene encoding fatty acid amide hydrolase (FAAH) and one in the pseudogene FAAH-OUT modulating FAAH expression, which are theorized to be responsible for her condition. FAAH is an enzyme involved in the metabolism of endocannabinoids like anandamide. Cameron has high levels of anandamide and other endocannabinoids.
She was first presented as a published case report in 2019 and was subsequently featured widely in the mainstream media. Development of pharmaceutical drugs (specifically FAAH inhibitors) for treatment of pain and psychiatric disorders has been encouraged by her case.
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